76ers vs. Knicks 2026 NBA Eastern Conference Semifinals Game 2 prediction, odds, pick

We are back for another NBA Playoff betting prediction and pick, and it’s time for Game 2 of the Eastern Conference semifinals between the Philadelphia 76ers and New York Knicks on Wednesday. The Philadelphia 76ers started off the series with a dud in Game 1 and will look to tie things up against the red-hot New York Knicks at Madison Square Garden on Wednesday night. Check our NBA odds series for the 76ers-Knicks prediction and pick.

The Philadelphia 76ers enter Game 2 of the Eastern Conference Semifinals looking to steal home-court advantage, coming off a beatdown by New York in the series opener. They’ve played physical basketball, winning six of their last eight postseason matchups, but are desperate to bounce back and avoid falling into a 0-2 hole, hoping for the road upset in this one.

The New York Knicks are currently commanding the series, successfully protecting Madison Square Garden with a dominant Game 1 performance on the back of Jalen Brunson’s 35 points. They’ve been a formidable force at home, winning nine of their last ten games in front of their raucous home crowd, and are hoping to maintain their momentum to defend their home floor once again as the betting favorites.

NBA odds courtesy of DraftKings

76ers vs. Knicks Odds

Philadelphia 76ers: +7.5 (-110)

New York Knicks: -7.5 (-110)

Over: 215.5 (-110)

Under: 215.5 (-110)

76ers vs. Knicks Key Injuries 

Philadelphia: Joel Embiid (ankle – Probable)

New York: None

76ers vs. Knicks Betting Trends

• The New York Knicks are 33-11 at home this season. The Philadelphia 76ers are 25-21 on the road.
• The 76ers have gone 16-29 as underdogs. The Knicks are 52-20 as the betting favorite.
• The Knicks are 49-41 ATS overall, 30-14 ATS at home. The 76ers are 49-42 ATS overall, 27-19 ATS on the road.
• The Knicks are 8-2 straight up, 3-7ATS in their last 10 games against the 76ers.
• The Knicks are 8-2 ATS over their last 10 games.
• The 76ers are 6-4 straight up and 7-3 ATS over their last 10 games.
• The total has gone UNDER in three of the Knicks’ last six home games.
• The 76ers are 3-2 ATS in their last 5 away games.

Keys to 76ers vs. Knicks Matchup

The Philadelphia 76ers find themselves reeling after a devastating 137-98 blowout loss to the New York Knicks in Game 1 of the Eastern Conference Semifinals. Nick Nurse’s squad must quickly regroup and find a way to contain a surging Knicks offense that shot a blistering 63% from the field. For Philadelphia to steal Game 2 at Madison Square Garden, Joel Embiid desperately needs to establish his rhythm early and bounce back from a highly inefficient 14-point performance.

On the other side of the floor, Jalen Brunson continues to be an unsolvable puzzle for the Sixers’ defense. Brunson masterfully orchestrated the offense with 35 points in the series opener, extending New York’s historic postseason streak of dominant victories. The Knicks’ supporting cast, bolstered by key contributions from Karl-Anthony Towns and Mikal Bridges, has made them a terrifying juggernaut that punishes every defensive lapse.

Philadelphia’s perimeter defense must aggressively pressure the ball, while Tyrese Maxey and Paul George have to drastically increase their scoring output to keep pace. If the Sixers allow another early offensive avalanche, New York will comfortably defend their home court and take a commanding 2-0 series lead. The overall stakes for Game 2 absolutely could not be higher.

76ers vs. Spurs Prediction and Pick

After a humiliating blowout in Game 1, expect the Philadelphia 76ers to come out swinging on Wednesday night with a much renewed sense of urgency. Tyrese Maxey and Paul George will undoubtedly step up to alleviate the offensive pressure on Joel Embiid, forcing a much tighter contest. However, the New York Knicks remain an absolute wagon at Madison Square Garden. Jalen Brunson is playing the very best basketball of his career, and the defense of Mikal Bridges, OG Anunoby and Mitchell Robinson make this Knicks squad incredibly difficult to beat on their home floor.

While Philadelphia’s pride will prevent another massive collapse, New York’s depth and home-court energy will ultimately prevail in the fourth quarter. The 76ers will make the necessary adjustments to keep the score within striking distance, but they lack the firepower to steal the outright win. Knicks win 112-108, and the 76ers cover the +7.5 spread.

Final 76ers vs. Knicks Prediction & Pick: San Antonio Spurs -12.5 (-115), UNDER 217.5 (-108)

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