Burnley vs Manchester City predictions and betting tips – Guardiola’s team to take charge of title fight

The Premier League title race is now in Manchester City’s hands. A 2-1 victory over Arsenal on Sunday has made Pep Guardiola’s team the new favourites to win the championship crown.

Can Burnley find a way to halt this in-form City side, or should we expect one-way traffic at Turf Moor on Wednesday evening?

• Manchester City to win both halves – 21/20 with Betfred
• Manchester City to win to nil – 10/11 with Casimba
• Antoine Semenyo to score any time – 4/6 with 247Bet

Burnley vs Manchester City head to head overview

• Date: Wednesday 22nd April.
• Kick-off: 8pm.
• Venue: Turf Moor, Burnley, England.
• Where to watch: Sky Sports Main Event.
• Referee: Andy Madley.
• VAR: Yes.
• Last meeting: 27 September 2025; Manchester City 5-1 Burnley
• Last 10 matches: Burnley – 0 wins; Manchester City – 10 wins; Draws – 0
• Favourite to win: Manchester City.

Burnley vs Manchester City predicted lineups

• Burnley expected lineup: Dubravka; Walker, Ekdal, Esteve, Hartman; Ward-Prowse, Florentino; Edwards, Ugochukwu, Anthony; Flemming.
• Manchester City expected lineup: Donnarumma; Nunes, Khusanov, Guehi, O’Reilly; Rodri, Silva; Semenyo, Cherki, Doku; Haaland.

Burnley vs Manchester City predictions

Advantage Manchester City.

A 2-1 victory over Arsenal on Sunday has made Pep Guardiola’s side the new favourites for the Premier League title.

City are still not top of the table, but they will rise there for the first time since the opening weekend if they beat Burnley on Wednesday.

There is still a long way to go in this two-way title tussle. Although City could be first by the weekend, Arsenal will then play twice more before Guardiola’s men are back in league action.

In a best-case scenario for Arsenal, they would be six points clear at the summit of the standings by the time City face Everton on May 4. And it is far from guaranteed that City will win every game from this point on.

Nevertheless, there is no doubt that the momentum has swung decisively towards Guardiola and co.

It was a pretty even game at the Etihad Stadium on Sunday, but City did a better job of taking the chances they created, as goals from Rayan Cherki and Erling Haaland got them over the line.

Depending on how West Ham United fare against Crystal Palace on Monday evening, a defeat for Burnley in this game could send them down to the Championship.

In truth, it is a matter of when rather than if relegation is confirmed for Scott Parker’s men, who lost 4-1 to Nottingham Forest over the weekend.

This looks like a straightforward assignment for City, who have the chance to knock Arsenal off top spot for the first time since October.

Burnley vs Manchester City betting tips

Will Manchester City have everything their own way against Burnley on Wednesday?

Expect one-way traffic at Turf Moor

Manchester City are currently one behind Arsenal on goal difference, which means they will at least draw level on that metric with a win at Turf Moor.

Guardiola will not settle for being level, though. The title could ultimately be decided on goal difference, so this feels like a golden opportunity for City to establish a healthy lead.

City won the reverse fixture 5-1 back in September, although the half-time score on that occasion was 1-1.

This time around, City look well positioned to win both halves. Burnley are struggling for both form and belief, and City are primed to take full advantage.

Tip Manchester City to win both halves at 21/20 with Betfred

Burnley have run out of steam

Sunderland and Leeds United will avoid an immediate return to the Championship this season, but Burnley are on their way back to the second tier. They have never really looked capable of staying up.

Parker’s charges have not been higher or lower than 19th place since losing to Chelsea in November. Only one of their last 23 top-flight matches has produced a win.

Burnley have scored the second-fewest goals in the division, while they have drawn a blank in three of their last five outings.

This is an excellent chance for Manchester City to keep their 14th clean sheet of the campaign.

Back Manchester City to win to nil at 10/11 with Casimba

Semenyo to the fore

The Premier League Golden Boot will almost certainly go to one of Haaland or Igor Thiago, but Antoine Semenyo is on track for a place on the podium.

Semenyo sits third in the charts having scored 10 goals for Bournemouth and five for Manchester City following his move north in the winter window.

He has been a little quieter of late, with Cherki taking charge of the City attack, but the Ghana international still has a big role to play.

Burnley’s backline shipped four goals to Nottingham Forest on Sunday, so Semenyo should cause Parker’s team problems at Turf Moor.

Go for Antoine Semenyo to score any time at 4/6 with 247Bet

Burnley vs Manchester City latest odds

Find the latest Bayer Burnley vs Manchester City betting odds here. All odds are provided by our recommended football bookmakers and are subject to change.

More Premier League predictions

We have plenty more Premier League predictions and picks – find our latest betting tips from expert punters in our match preview overview.

Important historical facts about Burnley vs Manchester City for betting

Manchester City have won each of their last 14 meetings with Burnley in all competitions.

Burnley, for their part, have triumphed in only one of the last 19 editions of this fixture. The Clarets’ most recent league victory at Turf Moor came way back in October.

About the author

Greg Lea

Greg Lea is a freelance football writer from London. He predominantly covers the Premier League and has had work published by the Guardian, FourFourTwo, ESPN and others.

Follow Greg on X: @GregLeaFootball

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