The Indiana Pacers could be without several key players, including star guard Tyrese Haliburton, when they host LeBron James, Jaylen Brown and the new-look Philadelphia 76ers on Wednesday night at 7 p.m. ET on ESPN.

Indiana (2-2) listed Haliburton as questionable with left hamstring tightness and soreness on its latest injury report Wednesday morning ahead of its matchup with Philadelphia (3-1). The Pacers are looking to bounce back from Monday night's 110-102 loss to the Milwaukee Bucks.

Haliburton, 26, has enjoyed an impressive start to the 2026-27 season after missing the entire previous campaign while recovering from a torn Achilles suffered in Game 7 of the 2025 NBA Finals against the Oklahoma City Thunder.

Through four games, the two-time All-Star is averaging a career-high 21.8 points, 9.5 assists, 4.5 rebounds and 1.3 steals per contest while shooting 51.6% from the field and 37% from three-point range in 33 minutes per game.

During Monday's loss to Milwaukee, Haliburton finished with 22 points, nine assists, six rebounds, one steal and one block while shooting 8-for-17 from the field, 4-for-10 from beyond the arc and 2-for-3 from the free-throw line across 35 minutes.

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Tyrese Haliburton headlines Pacers' lengthy injury report ahead of 76ers matchup

Haliburton is far from the only Indiana player dealing with an injury. The Pacers' latest report features 11 players, including several important rotation pieces.

Andrew Nembhard is questionable with neck stiffness and soreness, while Aaron Nesmith is probable with a left hamstring strain. Obi Toppin is also probable with a left hand sprain.

Meanwhile, Ivica Zubac remains out with a left ankle sprain, while T.J. McConnell will miss the contest with a right hamstring strain. Ben Sheppard is sidelined with a left meniscus tear, and Johnny Furphy remains out following right ACL surgery.

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Indiana also listed two-way players Kobe Brown, Jalen Slawson and Braden Smith as probable due to their G League assignments.

Philadelphia, meanwhile, enters Wednesday's contest with a considerably shorter injury report featuring four players.

Dominick Barlow is out with a lower back stress reaction, while Tacko Fall remains sidelined with a left quadriceps strain. Ariel Hukporti is unavailable due to a torn right Achilles, and Jabari Walker is out with left knee soreness.

The Pacers' injury concerns come as the franchise attempts to build momentum following a disappointing 2025-26 campaign that saw Indiana finish 19-63. With Haliburton back in the lineup, the team hopes to return to playoff contention, although Wednesday's lengthy injury report presents another early-season challenge.