One of the matchups of the week is the Buffalo Bills (6-1) going to Minnesota to take on the Vikings (6-1). It will be a battle between the Vikings top-tier defense and the Bills tremendous offense. Buffalo is a -3.5 point favorite and the game total has dropped from 48.5 to 46.5.
Minnesota is no longer undefeated after a 19-15 loss in Detroit. The bye week might have been the worst thing for the Vikings, as it cooled their hot streak. Minnesota barely survived Indianapolis, 16-10, and struggled all day against Detroit offensively. Kyler Murray did throw a season-high two touchdowns, but Minnesota was 3-of-11 on third and fourth downs, posted 266 total yards, and lost the time of possession battle (35:43-24:17). The Vikings haven’t cracked 300 yards of offense in either of their last two games, and their opponents went 13-of-28 on third downs. Minnesota won’t have it easy on money downs with Josh Allen in town.
Buffalo has won three straight games over the Rams (37-34 OT), Raiders (33-30), and Ravens (36-10). Buffalo has scored 24 or more points in every game this season and 36, 37, and 33 points in their three road games. Josh Allen scored three total touchdowns and recorded his fifth game of the year with both a passing and rushing score. James Cook had 101 total yards and a touchdown, while Dalton Kincaid and DJ Moore both surpassed 80 receiving yards and caught a touchdown. The Bills defense had it easy versus a third- or fourth-string quarterback last week, holding the Ravens to 68 passing yards. Baltimore ran 49 plays and had 144 total yards for 2.9 yards per play. Buffalo’s defense couldn’t have played any better.
Let’s dive into the numbers and see if we can’t find an additional sweat or two.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game details and how to watch Vikings vs Bills
· Date: Monday, November 9, 2026
· Time: 8:15 PM ET
· Site: U.S. Bank Stadium
· City: Minneapolis, MN
· TV/Streaming: ESPN
NBC Sports is your home for all the latest updates on this matchup, featuring live odds, player news, expert analysis, and predictions.
Latest Game Odds for Bills at Vikings
The latest odds courtesy of DraftKings:
· Moneyline: Buffalo Bills (-185), Minnesota Vikings (+154)
· Spread: Bills -3.5 (-102)
· Total: 46.5
The look ahead spread for this game was Buffalo -3 and a game total of 48.5, so we have movement to the Under and to Buffalo. Minnesota has failed to cover the last two games, but is an NFL-best 6-1 to the Under, and Buffalo is an NFL-best 3-0 to the Over on the road.
NBC Sports Bet Best Bets
Expert picks & predictions for Bills vs Vikings
Vaughn Dalzell (@VmoneySports) likes Buffalo to cover:
“I was on the Colts +6.5 and the Lions -3 over the past two weeks, and I will be fading them again in hopes of going 3-0 in that stretch. Minnesota is so overrated, and Buffalo is a Super Bowl contender. Buffalo’s defense will be able to step up enough to limit Kyler Murray and his tweaked hamstring. It’s Bills or pass.”
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Bills vs Vikings betting trends and stats
Bills betting trends
- Buffalo is 5-2 ATS, tied fourth-best
- Buffalo is 5-2 to the Over, tied third-best
- Buffalo is 2-1 ATS on the road
- Buffalo is an NFL-best 3-0 on the ML and 3-0 to the Over on the road
- Buffalo is 5-5 ATS (7-3 ML) in their last 10 as a road favorite
- Buffalo is 5-5 to the Over in their last 10 as a road favorite
Vikings betting trends
- Minnesota is 4-3 ATS
- Minnesota is an NFL-best 6-1 to the Under
- Minnesota is 1-2 ATS and 2-1 to the Under at home
- Minnesota is 5-5 ATS and on the ML as a home underdog with Kevin O’Connell
- Minnesota is 7-3 to the Under as a home underdog with O’Connell
- Minnesota is 9-13-2 ATS following a loss with O’Connell, ranking fifth-worst
- Minnesota is 12-12 to the Over and 12-12 on the ML following a loss with O’Connell
Peacock offers one of the most comprehensive live sports streaming lineups available today, bringing together the NFL, NBA, MLB, WNBA, Premier League, NCAA football, NCAA basketball, golf, motorsports, and major global sporting events in a single service.
Quarterback matchup for Bills vs Vikings
· Minnesota: Kyler Murray – Kyler Murray is questionable with a hamstring injury, but expected to play. Murray is coming off a season-high two passing touchdowns in the loss to the Lions. He posted 210 passing yards on 17-of-29 (58.6%) and 35 rushing yards on four carries. Murray was sacked three times, the fourth time he’s taken at least three sacks. Murray also tossed an interception, breaking a streak of three games without a pick. Murray has the second-highest red zone completion percentage (75%), but ranks 28th in red zone attempts (16). When Murray is blitzed or running play-action, he ranks near the bottom of the NFL in completion percentage at 49% and 54.8%.
· Buffalo: Josh Allen – Josh Allen recorded his fifth game with a passing and rushing touchdown this season versus Baltimore. Allen threw for 289 yards and ran for another 30 in the 36-10 win. This week will be much different for Allen and the Buffalo offense. Minnesota runs the fewest man coverage in the NFL at 5.3% and the second-most zone (86.5%). Allen has thrown the ball more versus zone than man this season and completes 69.7% of his passes versus zone (16th) and the seventh-best true completion percentage overall (73.9%). Allen will be tested for sure, but he thrives in chaos, which he will be under. Minnesota likes to blitz, but Allen has a 78.8% catchable-ball rate versus the blitz (4th) and a 71.7% completion percentage (5th).
Bills vs Vikings Injury Update
Bills injuries
- WR DJ Moore (shoulder) is questionable
- WR Joshua Palmer (hamstring) is questionable
- RT Spencer Brown (back) is questionable
- CB Dee Alford (ankle) is questionable
Vikings injuries
- QB Kyler Murray (ankle) is questionable
- OT Christian Darrisaw (shoulder) is questionable
- S Theo Jackson (quads) is questionable
Rotoworld still has you covered with all the latest and tools for the NFL, including game predictions, player props, futures, and trends!
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
- Drew Dinsick (@whale_capper)
- Vaughn Dalzell (@VmoneySports)
- Trysta Krick (@Trysta_Krick)
