The Jacksonville Jaguars' victory over the Philadelphia Eagles at Tottenham Hotspur Stadium in London proved to be bittersweet, as they lost a key member of their offensive unit was sidelined by a serious injury.

Offensive tackle Anton Harrison got hurt in the third quarter while blocking for running back Bhayshul Tutenon on a rushing play. Harrison appeared to grab his right knee and went down to the ground. He was eventually carted off to the locker room and did not return.

According to NFL Network's Ian Rapoport, Harrison will need to undergo surgery once the Jaguars return from London. They will face the Houston Texans at Wembley Stadium on Sunday.

“Depending on what the surgeon sees during the procedure, Anton Harrison is either out 3-5 weeks (likely IR) or 3-4 months (out for the regular season),” wrote Rapoport on X.

The 24-year-old protector had been a durable player since the Jaguars drafted him with the No. 24 pick in 2023, missing only three games.

The Jaguars exercised the fifth-year option on his contract in April.

Offensive tackle Walker Little is expected to fill the void left by Harrison. Little came in for Harrison when he exited against the Eagles. He is in his sixth season in Jacksonville.

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Despite losing Harrison, the Jaguars held on against the Eagles. Quarterback Trevor Lawrence went 24-of-39 for 331 yards and two touchdowns, while wide receiver Parker Washington had six catches for 124 yards and two touchdowns.

Cam Little delivered the game-winning field goal from 57 yards.

The Jaguars improved to 4-1, the second straight year they won four of their first five assignments.