The No. 11 Ohio State Buckeyes host the No. 23 Oregon Ducks on Saturday, November 7, in a Big Ten game with College Football Playoff stakes. Ohio State is 6-2 after a 30-18 loss at USC, while Oregon is 5-3 after beating Northwestern. Kickoff at Ohio Stadium is scheduled for 3:30 p.m. ET on CBS.

Both teams are playing without their starting quarterbacks. Ohio State turns to freshman Luke Fahey because Julian Sayin hurt his throwing arm. Oregon uses Dylan Raiola because Dante Moore is out with a concussion. Oregon is close to elimination, and Ohio State likely cannot afford another loss.

Oregon vs. Ohio State Odds

Oregon: +7.5

Ohio State: -7.5

Over: 46.5

Under: 46.5

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Oregon vs. Ohio State Key Injuries

Oregon's biggest loss is Moore, whom coach Dan Lanning does not expect back this season. Running back Jordon Davison, receiver Messiah Hampton and tight end Andrew Olesh are also out, along with defensive back Aaron Flowers, linebacker Brayden Platt, lineman Matthew Johnson and offensive linemen Trent Ferguson and Dave Iuli. Receiver Jeremiah McClellan is probable.

Ohio State is without Sayin, running back Ja'Kobi Jackson, offensive lineman Jaxon Powell and tight end Maxence LeBlanc. Receivers Brandon Inniss and Brock Boyd, linebacker Eli Lee and lineman Ian Moore are questionable. Coach Ryan Day confirmed Fahey will start.

Oregon Betting Trends

Oregon is 3-5 against the spread this season, and five of its eight games have gone over the total. The Ducks have also stayed within 13 points in every game, with losses by eight at Oklahoma State, two to UCLA and 11 at Illinois.

Raiola is the main reason to trust the offense. He threw for 336 yards and three touchdowns in last week's win over Northwestern. The Ducks also tie for fourth nationally with 49 passes defended, which could matter against a freshman quarterback.

The concern is a thin supporting cast. With Davison, Hampton and Olesh out, Raiola has fewer weapons than he would in a normal week. Ohio State's secondary will be a tougher test than Northwestern's.

Ohio State Betting Trends

Ohio State is 5-3 against the spread and 3-2 as a favorite of 7.5 points or more. Four of its eight games have gone over the total. The Buckeyes have covered in 80% of home games since the start of 2025.

Fahey has to play with confidence against an Oregon defense that has seen three Big Ten teams allow more passing touchdowns. Jeremiah Smith gives the offense an elite receiver, and one big play down the field could swing the game.

The pass rush is a possible weakness. Raiola should be able to exploit it, and the Buckeyes will need better play from the front four to protect their lead.

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Keys to the Matchup

Ohio State must protect Fahey and keep the game simple. The Buckeyes scored only 18 points at USC and will lean on Smith and a solid, though unspectacular, running game. Taking shots downfield to Smith can speed up a stalled offense.

Oregon needs to keep Raiola clean and avoid mistakes. Quick throws would offset Ohio State's pass rush and reduce the risk of turnovers. If the Ducks can stay within a score into the fourth quarter, they have a chance to steal the game.

The edge goes to the better defense and home field. Ohio State is the more talented team and has a clear advantage at the line of scrimmage. But with both teams on backup quarterbacks, the spread is less certain than the moneyline suggests.

Oregon vs. Ohio State Prediction and Pick

Ohio State should win at home, but Oregon should cover the 7.5-point spread. The Buckeyes have the stronger defense and Jeremiah Smith, which gives them a path to control the game. However, Luke Fahey is a freshman starter, and Ohio State scored only 18 at USC. Dylan Raiola's passing keeps the Ducks within one score, so the points hold value.

Prediction: Ohio State 27, Oregon 21