Mississippi State star running back Fluff Bothwell, who is second in the SEC in rushing yards this season, carried the ball once against Alabama before leaving Saturday's game with a lower-body injury.
ESPN's Katie George reported that it was a pre-existing injury for Bothwell, who was seen on the sideline in shorts and a walking boot.
He entered Saturday's game with 402 yards and three touchdowns on 73 carries.
Mississippi State lists Kolin Wilson and Xavier Gayten as co-backups at running back. Wilson is third on the team with 21 carries. He has rushed for 104 yards this season.
Quarterback Kamario Taylor is also a threat running the football. He has 185 rushing yards this season.