Mario Cristobal and his squad make their way to Indiana, as the No. 1 Miami Hurricanes visit the No. 11 Notre Dame Fighting Irish on Saturday night at 7:30 p.m. ET. It is time to continue the NCAA Football odds series with a Miami-Notre Dame prediction and pick.Miami enters the game sitting at 8-0. They started the season with a dominant 45-6 win over the Stanford Cardinal in Week 1. Since, the Hurricanes secured strong victories over FAMU, Wake Forest and Central Michigan. They have scored at least 33 points in each game, reaching as high as 77 points throughout the first four games. Their remarkable success have soared to the top spot in the AP Top 25, continuing their perfect start with wins over Clemson, Florida State, Pittsburgh, and North Carolina.

Meanwhile, Notre Dame stands with a 7-1 record so far. They opened the season with blowout wins over Wisconsin (41-13) and Rice (31-0) before beating down Michigan State (27-10), Purdue (49-10), North Carolina (37-26), and Stanford (58-7). However, their perfect start to the season ended after losing in a 28-24 upset to the then-No. 8 BYU Cougars. They bounced back with a 35-13 blowout win over Navy, but they see their CFP positioning at risk going into the Miami clash.

Miami and Notre Dame have met 28 times prior to this game, seeing the latter have 17 wins in contrast to Miami's nine victories while drawing once. The Hurricanes took the win back in 2025, winning the game 27-24.

Odds provided by BetOnline

Miami vs. Notre Dame Odds

Miami: +7 (-110)

Notre Dame: -7 (-110)

Over: 54 (-115)

Under: 54 (-105)

Miami vs. Notre Dame Key Injuries

Miami- TE Owen Ruskavich (Questionable), WR Joshua Moore (Out), RB CharMar Brown (Out), TE Luka Gilbert (Out)

Notre Dame- WR Quincy Porter (Out), QB Blake Hebert (Out)

Miami vs. Notre Dame Betting Trends

  • Over is 5-0 in Fighting Irish last 5 games following a straight up loss.

  • Over is 6-0 in Hurricanes last 6 games after allowing more than 280 yards passing in their previous game.
  • Over is 5-0 in Hurricanes last 5 games following a straight up win.
  • Home team is 4-0 ATS in their last 4 meetings.
  • Hurricanes are 4-0 ATS in their last 4 games as a road underdog.

Keys to Miami vs. Notre Dame matchup

Miami has been on fire as one of the best performing football teams this season, especially with how potent the offense has been. However, they will miss Malachi Toney's 73 catches for 1,027 yards and 13 touchdowns due to injury. Darian Mensah is at the center of that side's success eight games in, throwing for 2,425 yards and 25 touchdowns and one interception while adding two rushing scores to his name. Mark Fletcher Jr. is back in action and in great form throughout his appearances in the run game by racking up 94 carries for 457 yards and nine touchdowns. Javian Mallory follows him with 71 rushes for 495 yards and seven touchdowns. Cooper Barkate and Daylyn Upshaw look to have big roles with 50 combined receptions for 635 yards and six touchdowns.

On Miami's defense, they must find holes in Notre Dame's attack and prevent the quarterback from building momentum throughout the course of the game. The Hurricanes have balance in the tackling department, having no players over 44 tackles while seeing 14 players over 10 tackles. Mohamed Toure leads the unit with 44 tackles with his playmaking ability. JJ Dunnigan comes next with 37 tackles and 1.5 sacks, Marquise Lightfoot shines with his pass rushing of 29 tackles and seven sacks, while Justin Scott has 25 tackles and two fumble recoveries.

Notre Dame will emphasize the need to hit the big plays in this one. CJ Carr looks to have his biggest game of the season as the Fighting Irish fight for firm positioning in the CFP bracket. He has completed 148 out of 222 passes for 1,849 yards and 18 touchdowns and one interception while rushing 25 times for 86 yards and three touchdowns. Nolan James Jr. shines in the run game with 90 carries for 519 yards and eight touchdowns, while Jonaz Walton contributes with 69 rushes for 477 yards and four touchdowns. Jordan Faison leads the receiving corps with 38 catches for 497 yards and four touchdowns, while Micah Gilbert has 24 receptions for 430 yards and three touchdowns.

On defense, it is all about the combination of Drayk Bowen, Luke Talich, Leonard Moore, and Boubacar Traore. They stand out as the four defenders who lead in respective areas on that side of the ball, seeing Bowen lead the way with 45 tackles and two pass deflections. Talich flourishes with his playmaking with 36 tackles and two interceptions, Moore has 13 tackles and five pass deflections, while Traore recorded 24 tackles and 3.5 sacks.

Miami vs. Notre Dame Football Prediction and Pick

This matchup between Miami and Notre Dame looks to be a Game of the Year candidate in football conference action, seeing a lot of stakes for Notre Dame in particular. Notre Dame won't have Malachi Toney to worry about, but they will be busy with preventing Darian Mensah from getting everyone on the team involved throughout the night. This game will go down to the wire, but the Hurricanes might show why they are the best performing squad in the country so far this season. Miami gets the win in this one and covers, while the over also hits.

Final Miami vs. Notre Dame Prediction and Pick: Miami +7 (-110) and over 54 (-115)