49ers RB Christian McCaffrey expected to play through illness in Week 15

Despite a minor scare, Christian McCaffrey will remain in the San Francisco 49ers’ Week 15 lineup when they face the Tennessee Titans.

The star running back missed practice early in the week with his illness, but was a full participant on Friday and is expected to play in Week 15, Cam Inman of the Bay Area News Group reported.

After only appearing in four games in 2024, McCaffrey has yet to miss a week in 2025. The 29-year-old is 151 rushing yards shy of his fifth career 1,000-yard season with four regular season games remaining.

The 49ers tend to be cautious with their stars late in the year to prepare for the playoffs, suggesting that McCaffrey should play with few limitations. Brian Robinson Jr. has topped 40 rushing yards in three of the last five games and will be ready to spell McCaffrey if necessary.

Even if he plays wounded, McCaffrey has an excellent opportunity to shine in Week 15. The Titans have been below average against the run all season and enter the matchup allowing 4.5 yards per carry, 11th-highest in the league.

This is a developing story.

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