Finding reliable running back production on the waiver wire can be challenging. That's especially true when injuries and uncertain workloads complicate fantasy football decisions. Week 6 presents several opportunities for managers willing to look beyond established starters. These options can carry different levels of risk. That makes workload security and recent production essential considerations. Whether you need a flex starter or a short-term replacement because of injuries, choosing the right back could provide a crucial advantage. Here is how four candidates stack up heading into Week 6.
Cam Skattebo, NYG (vs. NO)

Cam Skattebo remains an appealing streaming option after delivering another reasonably productive performance in Week 5. He rushed 13 times for 59 yards and caught two of his three targets for 12 yards.
Consistency has been one of Skattebo's biggest selling points. He has rushed for more than 55 yards in four of his first five contests. Although his latest performance did not produce a touchdown, his ability to contribute in multiple facets of the offense helps protect his fantasy value when scoring opportunities are limited.
The upcoming matchup against the New Orleans Saints offers another chance to build on that production. If the Giants continue giving Skattebo a meaningful share of the backfield touches, he should have opportunities to accumulate useful rushing yards and contribute as a receiver. His versatility is especially valuable in point-per-reception formats. That's where even a handful of catches can make a difference.
Skattebo is not necessarily a player who needs a massive workload to justify a flex start. Of course, touchdown opportunities would significantly raise his ceiling. Skattebo is the safest option on this list for managers seeking a relatively steady workload and contributions in both the rushing and receiving games.
Woody Marks, HOU (@ JAC)
Woody Marks could become one of the more valuable running back streamers of Week 6 if Houston gives him the lead role. With David Montgomery considered week-to-week, Marks is reportedly expected to carry the load for the Texans. That potential workload makes him difficult to overlook. Marks handled 19 touches in Week 5, demonstrating that Houston is willing to give him substantial involvement.
Marks may not offer explosive playmaking ability, but volume can compensate for limited efficiency. If Houston gives Marks the backfield largely to himself, he could provide low-end RB2 or high-end RB3 value.
The main concern is whether he can turn those opportunities into efficient production. Nevertheless, running backs with predictable workloads are often worth prioritizing on the waiver wire. Marks is a strong volume-based streamer, particularly if Montgomery remains sidelined.
Dameon Pierce, PHI (vs. CAR)
Dameon Pierce is a more speculative option after a difficult first outing with Philadelphia. He rushed 11 times for just 14 yards. He also recorded negative receiving yardage on two catches in the Eagles' 19-17 loss to Jacksonville.
Pierce received additional opportunities after Will Shipley exited early with a foot injury, though. Elevated to the active roster that week, Pierce made his Eagles debut but struggled to generate momentum against Jacksonville's defense.
Now, the uncertainty surrounding Philadelphia's backfield is the biggest factor to watch. The Eagles have dealt with injuries at running back. Saquon Barkley, though, could return in Week 6. If Barkley is available, Pierce's opportunities could shrink considerably. Shipley's status will also influence how the team distributes its touches.
Pierce's value therefore depends less on his Week 5 production than on how Philadelphia's backfield looks before kickoff. If injuries leave him with a meaningful workload, he could be a desperation flex option. Pierce is a deep-league contingency option, not a priority starter. Monitor Barkley and Shipley's availability before considering him for your lineup.
MarShawn Lloyd, GB (vs. DAL)
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MarShawn Lloyd enters Week 6 with a two-touchdown performance. In Green Bay's 31-7 win over Chicago, Lloyd rushed 10 times for 31 yards while catching one of two targets for six yards.
The touchdowns were encouraging, but his overall efficiency remains a concern. Lloyd has rushed for fewer than 40 yards in each of the first five games. That limits his value somewhat. His role near the top of Green Bay's backfield rotation creates opportunities, yet the rushing production has not consistently followed.
A matchup against Dallas gives Lloyd another chance to turn his role into a more complete fantasy performance. Lloyd is a touchdown-dependent flex gamble. His scoring upside is real, but managers should not treat one productive fantasy outing as proof of a reliable weekly role.
Final Takeaway
Skattebo offers the steadiest profile. Marks has the most compelling workload opportunity. Pierce depends on Philadelphia's injury situation. Lloyd needs more consistent yardage. Check final backfield updates before locking in your Week 6 lineup.

