After playing Week 1 with (almost) a fully healthy roster, with only Jonathan Greenard on the injury report after Eli Stowers was placed on IR, things aren't quite so clean for the Philadelphia Eagles in Week 2.

On their final injury report of Week 2, the Eagles featured six players but only two with game statuses. Jalen Carter, Hollywood Brown, Cooper DeJean, and Elijah Moore all missed time during the week but are good to go, while Andrew Mukuba is questionable and Greenard remains out as he works back from the summer pectoral injury.

While there were plenty of talking points coming out of Week 1 on offense, from the big passing plays downfield, to the Eagles' deceptive run struggles and rookie Makai Lemon's negative passing yards, on defense, one rose above the rest: Carter injuring his wrist.

Now granted, Carter still played the lion's share of the snaps for Vic Fangio against the Washington Commanders, playing 66 of a possible 70 defensive snaps, but he was seen at practice days later with a cast on his wrist and thus may not be 100 percent in Nashville against the Tennessee Titans.

And yet, even if Carter may be in pain, it hasn't forced him out of action, as he is currently a go to play in Week 2, alongside Brown, DeJean, and Moore, who were limited in some way during practice.

Mukuba also found himself on the injury report during the week, but unlike Carter, he remains questionable for the contest and will likely be a gameday decision for Fangio. If Mukuba, like Greenard, is unable to play in Week 2, the Eagles do have a contingency in place, as they've officially called up rookie safety Maximus Pulley from the practice squad for the game, but it's unlikely the former Wofford Terrier would get much action on defense, considering Fangio's propensity for playing more experienced players more often than not.

On the Titans sideline, Tennessee included three players on their final report of Week 2, with cornerback Cor'Dale Flott questionable with a quad and linebackers Cedric Gray and James Williams questionable with a concussion and elbow, respectively.

Fortunately, while the Eagles have the potential to be without higher-profile players, that shouldn't slow them down too much in Week 2, as their depth held strong against the Commanders and should remain strong, at least against an opponent like the Titans.

Friday’s Injury Report#PHIvsTEN pic.twitter.com/gdkNrruSZ3

— Philadelphia Eagles (@Eagles) September 18, 2026

The Eagles can replace Jonathan Greenard better than Andrew Mukuba

In Week 1, the Eagles opted to roll with a four-man outside linebacker rotation rushing off the edge, largely sticking with their starters in true Fangio fashion, with some supplemental work off the bench from their free agent additions.

Jalyx Hunt led the team with 53 snaps and made a serious impact on the game even if his stats – three tackles  – didn't show it. As has become the norm, Hunt can play the pass, the run, or even drop into coverage, and while he didn't get to Jayden Daniels, he was able to force him out of the pocket and take him off schedule. Nolan Smith followed close behind with 47 snaps, holding down the opposite side of the field as a three-down edge rusher, and behind him, the Eagles rotated in Arnold Ebiketie and AJ Epenesa, who had 28 and 12 defensive snaps, respectively.

Would the Eagles like to finish out a game with more than one sack, especially when it came from their back seven? Most certainly, but in Week 1, Cam Ward was sacked three times, and the Titans' offensive line hasn't exactly been considered the best in the NFL, so that problem could fix itself even without Greenard leading the rush.

At safety, however, things get a bit more complicated if Mukuba can't play because the Eagles simply don't have a ton of depth at the position, seemingly by choice.

Against the Commanders, Mukuba was one of only five Eagles players who logged all 70 defensive snaps alongside Zack Baun, Riq Woolen, Quinyon Mitchell, and DeJean. When the Eagles suffered an injury at safety in Week 1, with Marcus Epps leaving the field for a bit to get his shoulder worked on, Fangio turned to Michael Carter II as their sixth defensive back off the bench, logging six snaps.

But if Mukuba can't go? Then the plan may have to be adjusted over a full game, as DeJean does his best work in the slot, not as a base safety. MC2 and DeJean can play the same position and are more or less interchangeable on defense schematically, but when it comes to “true” safeties on the 53-man roster, the Eagles really only have two in Epps and Mukuba after losing Andre' Sam to a season-ending preseason injury against the Cincinnati Bengals.

Against an inexperienced quarterback like Ward, who only completed 19 of his 32 passing attempts in Week 1 against the Jets for 140 yards and a touchdown, being light at safety might not be the worst-case scenario. The Eagles lost Mukuba last year and were able to hold things down with Epps as a veteran option from their practice squad. But against a team like the Chicago Bears in Week 3? Goodness, Fangio can't want to rely on a cobbled-together secondary against a passing game that put up 269 aerial yards in Week 1.

Fortunately, there's still a chance Mukuba could play in Week 2 and that he could be back in time for Week 3 if things are close, but this injury does highlight that, unlike on the edge, the Eagles are rather light at safety and should consider ways to address that heading into the middle of the season and the trade deadline.