Dak Prescott lost a fumble that allowed the Colts to take a 7-3 lead. The Cowboys quarterback rebounded, though.
He led the Cowboys on a seven-play, 65-yard drive to regain the lead 10-7.
Prescott threw a 10-yard touchdown pass to Jake Ferguson, who held on despite being well covered, on fourth-and-2.
The Cowboys have outgained the Colts 111 to 34, with Prescott going 8-of-12 for 65 yards.
Tyler Goodson has four carries for 26 yards and Javonte Williams six for 18.