Bills-Lions Fantasy Football Week 2 Start ‘Em, Sit ‘Em

Thursday night's showdown between the Bills and Lions carries the highest total of Week 2 at 53.5 points, with Buffalo favored by 4.5. That kind of shootout projection makes this game a fantasy goldmine, but not every skill player is equally positioned to cash in. Here's who to trust and who to leave on your bench for this Highmark Stadium opener.

Week 2 Start ‘Em

Jared Goff, QB, Lions — Goff opened the season by completing 26 of 39 passes for 206 yards and two touchdowns against New Orleans. While the yardage total was modest, the matchup context matters more here: this is a Thursday night game with a 53.5-point total against a Bills defense that just gave up 31 points and 334 passing yards to Josh Allen. Goff has a proven track record of thriving in shootouts with Detroit's loaded receiving corps of Amon-Ra St. Brown, Sam LaPorta and Jahmyr Gibbs drawing coverage away from him. Expect a bounce-back yardage total and multiple touchdowns in a game both offenses are expected to move the ball freely.

DJ Moore, WR, Bills — In his Bills debut, Moore led the team with eight targets and turned five catches into 100 yards and a touchdown. That target volume, paired with the chemistry he flashed with Allen in the preseason (three catches for 61 yards on just two drives), signals he's already Buffalo's clear No. 1 read. Detroit's defense surrendered plenty of yardage in its Week 1 overtime win, and with the game projected for 53-plus combined points, Moore's target share alone makes him a must-start WR2 with upside.

Dalton Kincaid, TE, Bills — Kincaid torched Houston for a career-high 130 yards on five catches out of six targets in Week 1, including back-to-back explosive plays of 40 and 35 yards in the fourth quarter. He actually out-gained fellow newcomer DJ Moore by 30 receiving yards while tying Khalil Shakir for second on the team in targets. Against a Lions defense that just allowed a wild, high-scoring finish to the Saints, Kincaid's role as Josh Allen's chunk-play safety valve makes him a locked-in TE1 this week.

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Week 2 Sit ‘Em

Jameson Williams, WR, Lions — Williams was a major letdown in Week 1, hauling in just 4 of 9 targets for 45 yards and no touchdowns, with nearly half of his yardage coming on a single 22-yard catch. His catch rate fell below 50 percent, and reports indicate he and Goff simply weren't in sync throughout the game. Coming off back-to-back 1,000-yard seasons, Williams has clear bounce-back potential eventually, but the immediate chemistry issues with Goff and inconsistent target efficiency make him a risky start against a Bills secondary that, while beatable, shouldn't be counted on to make Williams a priority sit-turned-start just yet. Bench him in favor of safer options until the target share translates to production.

Khalil Shakir, WR, Bills — Shakir caught just 4 of 8 targets for 50 yards and no touchdowns in the opener, and while he tied for the team's second-most targets, his 12.5 yards-per-catch average was the lowest of Buffalo's pass catchers who saw real volume. With Moore now soaking up the highest-value targets and Kincaid emerging as the big-play threat, Shakir has been squeezed into a low-ceiling, high-target-but-low-yield role. He's a fringe flex at best in PPR formats and not a confident start in a game where two other Bills weapons project for significantly more fantasy production.

With both offenses licensed to air it out on national television, target volume and recent performance data point clearly toward Kincaid, Moore and Goff as this week's smartest plays, while Shakir and Williams carry too much uncertainty to trust in competitive lineups.