Kalen DeBoer and his squad make their way to Louisiana, as the No. 5 Alabama Crimson Tide visit the No. 14 LSU Tigers on Saturday afternoon at 3:30 p.m. ET. It is time to continue the NCAA Football odds series with an Alabama-LSU prediction and pick.
Alabama enters the game sitting at 6-2. They started the season with a 48-10 win over the East Carolina Pirates in Week 1. They went on to secure quality wins over the Kentucky Wildcats (45-17), the Florida State Seminoles (50-36), the South Carolina Gamecocks (49-18) and the then-No. 16 Mississippi State Bulldogs (56-23). However, their hot start cooled off when they lost to the then-No. 2 Georgia Bulldogs by a 20-17 score. Suffering another loss to the then-No. 14 Tennessee Volunteers, they got back on track with a 31-20 win over the Texas A&M Aggies.
Meanwhile, LSU is 6-2 at the moment. They opened the season with a dominant 51-10 win over the Clemson Tigers. After a 45-14 blowout win over Louisiana Tech, they took a step back after falling 32-24 to the then-No. 8 Ole Miss Rebels. They bounced back with wins over No. 23 Texas A&M 35-6 and McNeese (63-14) before falling down to earth with a 35-34 upset loss to the Kentucky Wildcats. The squad has since recovered with dominant victories over then-No. 16 Mississippi State (31-0) and Auburn (38-17).
Alabama and LSU share a long history of playing against each other in football. The former boasts 58 wins over LSU's 27 victories while they drew five times. Alabama took the win back in November 2025, winning the game 20-9. The Crimson Tide have won five of the last six contests dating back to 2020, as LSU last won in 2022.
Alabama vs. LSU Odds
Alabama: +6 (+100)
LSU: -6 (-120)
Over: 52.5 (-115)
Under: 52.5 (-105)
Alabama vs. LSU Key Injuries
Alabama- TE Josh Ford (Questionable), WR Aubrey Walker (Out), WR Ryan Coleman-Williams (Out), EJ Crowell (Questionable), WR Cederian Morgan (Questionable)
LSU- TE Trey'Dez Green (Questionable), S Dashawn Spears (Out), RB Raycine Guillory Jr. (Questionable), WR Phillip Wright III (Out), WR Tre' Brown (Questionable), LB Tylen Singleton (Questionable)
Alabama vs. LSU Betting Trends
- Crimson Tide are 5-0 ATS in their last 5 games following a bye week.
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Tigers are 4-0 ATS in their last 4 games after accumulating more than 450 total yards in their previous game.
- Over is 4-0 in Crimson Tide last 4 games after scoring less than 20 points in their previous game.
- Crimson Tide are 5-1 ATS in their last 6 meetings in Louisiana State.
- Over is 5-1 in Tigers last 6 games after allowing less than 20 points in their previous game.
Keys to Alabama vs. LSU football matchup
Ryan Coleman-Williams, a junior star receiver who has 23 receptions for 415 yards and four touchdowns, will miss the game due to injury. The team ruled him out earlier this week due to a concussion he recently suffered against Georgia. Sophomore Lotzeir Brooks will serve as Keelon Russell's primary target. Brooks has had similar production to that of Coleman-Williams, making 29 catches for 488 yards and a touchdown. Russell looks to maintain his passing efficiency, throwing for 2,057 yards and 15 touchdowns and five interceptions while rushing 66 times for 251 yards and five touchdowns. Daniel Hill leads the run game with 71 carries for 332 yards and four touchdowns, while Traeshawn Brown comes next with 64 rushes for 324 yards and five touchdowns.
Article Continues BelowThrough eight games this season, Alabama has come up with 12 interceptions. From those 12, five have been returned for touchdowns. Red Morgan, Yhonzae Pierre, Dijon Lee Jr., and Luke Metz have all have generated pick-six scores. Metz boasts 57 tackles and two fumble recoveries on top of the pick-6 interception this season. Caleb Woodson has 63 tackles and two sacks and two pass deflections, while Bray Hubbard recorded 41 tackles and three pass deflections and two interceptions.
The Tigers possess one of the best offenses in the country, shining as a fierce squad in Year 1 under Lane Kiffin so far. They rank sixth in the country with 510 yards per game, seventh in passing offense with 318 yards per game, 29th in rushing offense with 192 yards per game, and ninth in scoring offense with 40.1points per contest. During LSU's past two games, lopsided victories over Mississippi State and Auburn, quarterback Sam Leavitt did not throw an interception. Those performances contrasted with Leavitt's first six games, during which he threw at least one interception in each contest and eight total. Leavitt has completed 70.3% of his passes this season for 2,173 yards and 17 TDs. He also has rushed for 324 yards and eight scores. Dilin Jones leads the run game with 149 carries to his name for 657 yards and six touchdowns. Winston Watkins Jr. leads receivers with 37 catches for 487 yards and two touchdowns, while Jackson Harris commands with 36 receptions for 634 yards and seven touchdowns.
LSU also shines as an elite squad on the defensive side of the ball. They rank fifth in yards allowed with 258.1 yards per game, 15th in passing defense with 172.8 yards per game, eighth in rushing defense with 85.4 yards per game, and 15th in scoring defense with 16 points per contest. TJ Dottery leads the unit with 58 tackles, three pass deflections and two forced fumbles. Princewill Umanmielen has been remarkable as a pass rusher with 32 tackles and 8.5 sacks, while Jordan Ross has a pick-6 touchdown to his name with 23 tackles and five sacks to go with it.
Alabama vs. LSU Prediction and Pick
This matchup between Alabama and LSU stands out as an intriguing matchup. Alabama may boast a higher ranking than LSU, but the team has suffered lapses on both sides of the ball that leave them vulnerable to the Tigers' explosive offense. Their CFP trajectory hinges on how they perform against LSU, one that Lane Kiffin and the Tigers will look to shake up in convincing fashion at home. LSU gets the win in this one and covers, while the over also hits.
Final Alabama vs. LSU Prediction and Pick: LSU -6 (-120) and over 52.5 (-105)