The undefeated San Francisco 49ers (5-0) host the Washington Commanders (1-3-1) on Monday Night Football as -7.5 point favorites. The Commanders are coming off 27-27 tie versus the Giants whereas the 49ers beat the Seahawks 32-29.
The 49ers and Seahawks combined for seven turnovers last week with the 49ers committing three of them. San Francisco is one of three teams that remain undefeated (Chiefs, Vikings) and have an NFL-best +61 point differential. Brock Purdy is collecting MVP hype as he always does in Brocktober and he’ll have a soft matchup at home.
Washington’s pass defense could be in for a long day. The Commanders gave up 326 passing yards to Jameis Winston and three touchdowns last week and struggled to stop the run in London the week prior as Jonathan Taylor ran for 95 yards and two touchdowns. The 49ers will be without Deebo Samuel (hamstring) and listed Mike Evans (ribs) and Lucas Patrick (illness) as questionable ahead of this game. Perhaps that slows down the 49ers attack, and if we’re being honest, the Commanders need any help they can get as Washington is looking like a prime candidate for a top five pick.
Let’s dive into the numbers and see if we can’t find an additional sweat or two.
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Game details and how to watch Commanders at 49ers
· Date: Monday, October 19, 2026
· Time: 8:15 PM ET
· Site:
· City: Santa Clara, CA
· TV/Streaming: ESPN
NBC Sports is your home for all the latest updates on this matchup, featuring live odds, player news, expert analysis, and predictions.
Latest Game Odds for Commanders at 49ers
The latest odds courtesy of DraftKings:
· Moneyline: San Francisco 49ers (-455), Washington Commanders (+350)
· Spread: 49ers -7.5 (-110)
· Total: 52.5
The spread opened San Francisco -5.5 and has been bet out to -7.5, while the total moved from 50.5 to 52.5.
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Commanders at 49ers betting trends and stats
- San Francisco is 4-1 ATS and 3-2 to the Over
- Washington is 2-3 ATS and 4-1 to the Over
- San Francisco is 3-0 on the ML and 2-1 ATS at home
- San Francisco is 2-1 to the Over at home
- Washington is 1-1 ATS and 0-2 on the ML on the road
- Washington is 2-0 to the Over on the road
- The Commanders are 2-2 ATS as an underdog and 3-1 to the Over
- The 49ers are 2-1 ATS as a favorite and 2-1 to the Over
- The 49ers are 3-1 ATS following a win this season but 8-8-1 since the start of 2025
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Quarterback matchup for Commanders at 49ers
· Washington: Jayden Daniels – In his second start back from injury, Jayden Daniels threw for 199 yards and gashed the Giants for 103 rushing yards on nine carries and two touchdowns. It was his best game of the young season. Daniels has yet to throw an interception and is a constant threat to run, but he’s struggled with the deep ball and his reads in the red zone. Daniels has a 16.7% completion percentage on deep balls (36th) and 44.4% in the red zone (31st). He also ranks 31st with a clean pocket when it comes to completion percentage (60.3%).
· San Francisco: Brock Purdy – Purdy is top five at most sports books for MVP this season as the 49ers are 5-0. Purdy has 13 touchdowns to two picks and a 69% completion percentage. Purdy is coming off a season-low 189 passing yards, and threw two touchdowns to one interception. After four-straight games of not being sacked, Purdy was sacked three times in the 32-29 win at Seattle. Purdy has thrown at least two touchdowns in all five games and ran for at least 29 yards up until last week.
Commanders at 49ers Injury Update
- Washington RB Jacory Crowsky-Merrit (groin) is out
- Washington WR Stefon Diggs (hamstring) is questionable
- Washington C Lucas Patrick (illness) is questionable
- Washington DE Javon Kinlaw (ankle) is questionable
- Washington S Nick Cross (illness) is questionable
- Washington QB Marcus Mariota (knee) is out
- San Francisco WR Mike Evans (ribs) is questionable
- San Francisco WR Deebo Samuel (hamstring) is out
- San Francisco DE Nick Bosa (knee/calf) is out
- San Francisco LB Dre Greenlaw (out) is suspended
- San Francisco DT Gracen Halton (quad) is questionable
- San Francisco SS Marcus Sigle (ankle) is out
- San Francisco CB Upton Stout (shoulder) is questionable
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