NFL Week 17 injury roundup: Amon-Ra St. Brown, Trent Williams and more

The NFL enters its final regular-season weekend with injuries reshaping playoff paths across the league. As teams prepare for Week 18, health has become just as decisive as matchups, altering postseason positioning and forcing difficult decisions across both conferences. This Week 17 injury roundup highlights the most impactful situations and examines how the latest injury developments could influence playoff momentum heading into January.

Several contenders absorbed major blows over the weekend, while others watched key contributors fight through injuries in games that carried significant stakes. As playoff-related injuries continue to mount, coaching staffs are now walking a fine line between urgency and preservation. The final Sunday of the regular season will test not only roster depth, but judgment.

Luther Burden III delivered another statement performance for the Chicago Bears before suffering a frightening injury late in a loss to the San Francisco 49ers. The Bears wide receiver went down with a quadriceps injury on the final play of a 42-38 loss to the 49ers and was carted off after finishing with 138 receiving yards and a touchdown. Burden has already shattered multiple franchise rookie records and remains the focal point of Chicago’s offense. Early indications suggest the injury may not be severe, but his status for the Week 18 matchup vs. the Detroit Lions remains uncertain. With playoff seeding and divisional positioning at stake, his availability could significantly impact the NFC North race.

Trent Williams suffered one of the most unusual injuries of the weekend. The 49ers left tackle strained his hamstring on the opening play while chasing down a defender following an interception. Despite scoring 38 points without him, San Francisco’s offensive structure changes dramatically when Williams is absent. Hamstring injuries are particularly troublesome for linemen, and any missed time would leave Brock Purdy exposed on his blindside during a critical push for the conference’s top seed.

Jordan Love continues to shape the Green Bay Packers’ postseason outlook without taking a snap. The Packers quarterback missed Week 17 while recovering from a concussion sustained the previous week, with a lingering shoulder issue further complicating his recovery timeline. Without Love, Green Bay’s offense struggled to maintain rhythm and sustain drives, placing additional stress on its defense. Week 18 carries major playoff implications, and Love’s clearance through protocol could determine whether the Packers can truly compete or simply attempt to survive.

Geno Smith suffered what appears to be a season-ending injury for the Las Vegas Raiders. The Raiders quarterback sustained a high ankle sprain late in a loss to the New York Giants after his foot was stepped on during an interception attempt. High ankle sprains typically require an extended recovery period, effectively bringing his 2025 season to an end. With Smith sidelined, Las Vegas shifts fully into evaluation mode, using Week 18 to assess younger players and begin shaping offseason plans.

Sauce Gardner attempted to return for the Indianapolis Colts but exited early after re-aggravating a calf injury. After missing three games, Gardner returned only to experience tightness in the same leg, prompting Indianapolis to remove him as a precaution. Soft tissue injuries often linger, and with playoff hopes still alive, the potential loss of the Colts’ top cornerback would be a significant setback. Indianapolis’ defensive scheme relies heavily on Gardner’s ability to neutralize opposing top receivers.

Amon-Ra St. Brown appeared on the injury report as a day-to-day concern after exiting late in the Detroit Lions’ Week 17 clash with the Minnesota Vikings due to a knee issue. St. Brown remains the engine of the Lions’ passing attack and Jared Goff’s most trusted option on third down. Detroit hosts the Chicago Bears in Week 18 with division implications looming, and any limitation would force the Lions to adjust their offensive approach against a Bears defense built on consistent pressure.

Several other injuries quietly reshaped rosters across the league. Darnell Washington suffered a broken arm for the Pittsburgh Steelers, ending his season and weakening their run-blocking packages. Davante Adams aggravated a hamstring issue for the Los Angeles Rams, raising the possibility of rest as Los Angeles shifts its focus toward the future. Marvin Harrison Jr. played limited snaps for the Arizona Cardinals due to a lingering heel injury, suggesting another reduced role in Week 18.

Rashid Shaheed entered concussion protocol for the Seattle Seahawks, placing his availability in doubt at a critical time. Noah Sewell tore his Achilles for the Chicago Bears, delivering a devastating blow to linebacker depth and special teams contributions. Terrel Bernard’s calf injury now places the Buffalo Bills’ defensive communication at risk entering the postseason, where cohesion and timing become increasingly vital.

As the NFL approaches its final Sunday, injuries may shape outcomes more than matchups. The Bears and Lions prepare to face off while carefully managing star receivers. The 49ers’ pursuit of the top seed hinges on protection up front, while the Packers and Colts wait anxiously on medical updates that could ultimately determine their playoff fates.

The Week 17 injury roundup underscores a familiar truth that health often determines January success, and the teams that emerge from Week 18 intact will carry the greatest advantage into the postseason.

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