The Minnesota Vikings will be facing the Buffalo Bills on Monday Night Football, and they have some key injuries heading into the matchup. The biggest one happens to be Kyler Murray, who suffered a hamstring injury against the Detroit Lions last week. It was evident early in the week that Murray wouldn't be playing in the next game, and he didn't log any practices either.

That means Carson Wentz will be the QB1 this week, and this is familiar territory for the quarterback after he started earlier in the season and got the Vikings a win.

Wentz starting shouldn't have that much of an effect on the offense, but it could make sense why some things will be a little different. Murray is a mobile quarterback and uses his legs a lot, while Wentz could stay in the pocket and make plays, but also isn't afraid to do it himself.

For Justin Jefferson, nothing should change with his production, and it wouldn't be a surprise if he saw more targets. Usually, backup quarterbacks tend to go to their safest option, and Jefferson has the skills to go up for almost any ball that comes his way.

Another player who could see a lot of targets is T.J. Hockenson, who has become a safety blanket in the Vikings' offense.

The Vikings will also be without Demond Claiborne and Jauan Jennings against the Bills. The offense will definitely have to have a next-man-up mentality, but they've been dealing with injuries on that side of the ball throughout the season and have still won games.

As always, the defense will be key to the Vikings' success, but they'll have their hands full with Josh Allen, who is once again playing at a high level this season.