Josh Allen made the first regular-season game in Highmark Stadium memorable for Bills fans.
The quarterback threw three touchdown passes and ran for two in a dominant 41-31 win over the Lions. The Bills improved to 2-0, while the Lions fell to 1-1.
Allen now has four career games with three touchdown passes and two rushing touchdowns. No other player in NFL history has more than two (Kordell Stewart), according to NFL Researcher.
Allen completed 20 of 31 passes for 248 yards and three touchdowns. His scoring tosses went for 43 yards to Josh Palmer, 1 yard to Dawson Knox and 16 yards to Dalton Kincaid. Palmer has two catches for 77 yards and two touchdowns this season, having caught the game-winning touchdown in the win over the Texans on Sunday.
Kincaid caught seven passes for a team-leading 95 yards.
The Bills lost wide receiver DJ Moore to a shoulder injury and a stinger in the first half.
Allen also ran for 69 yards and two touchdowns on 14 carries, topped only by James CookâÂÂs 21 carries for 135 yards. Cook scored the teamâÂÂs last touchdown on a 1-yard run with 2:50 left to seal it.
The Bills outgained the Lions 446 to 355, were 5-for-5 in the red zone and went 9-of-12 on third down.
Buffalo scored touchdowns on its first four possessions and punted only twice all night.
The Lions, who blew a 21-0 lead to the Saints last week before winning in overtime, fell behind 21-0 and trailed 27-10 at halftime. They twice pulled to within 10 points when the game was still in reach, but Allen and the Bills answered twice.
DetroitâÂÂs last touchdown, which pulled it to within 10 again, came with 1:42 left as as Amon-Ra St. Brown scored his second touchdown. The Bills, though, recovered the onside kick.
Lions quarterback Jared Goff was 26-of-38 for 327 yards and four touchdowns after a slow start. Goff reached 40,000 yards in his 153rd game, the sixth-fastest for any quarterback.
St. Brown caught nine passes for 142 yards and two touchdowns, and running back Jahmyr Gibbs had 16 carries for 52 yards and caught six passes for 61 yards and a touchdown.
Bills outside linebacker Greg Rousseau, who had two sacks and two forced fumbles in the season-opening win over the Texans on Sunday, had two sacks and a forced fumble against the Lions.