Mario Cristobal and his squad make their way to South Carolina, as the Miami Hurricanes visit the Clemson Tigers on Saturday night at 7:30 p.m. ET. It is time to continue the NCAA Football odds series with a Miami-Clemson prediction and pick.

Miami enters the game sitting at 4-0. They started the season with a dominant 45-6 win over the Stanford Cardinal in Week 1. Since, the Hurricanes secured strong victories over FAMU, Wake Forest and Central Michigan. They have scored at least 33 points in each game, reaching as high as 77 points throughout the first four games. They are firmly inside the top five of the latest AP poll, controlling the fourth spot.

Meanwhile, Clemson stands with a 3-1 record so far. They opened the season in brutal fashion against LSU. They embarrassed themselves on the road, falling in a 51-10 blowout defeat. The Tigers have since bounced back with wins over Georgia Southern, North Carolina and California. However, they only won these games by a combined 37 points (12.3 points per game), showing they have had challenges in their latest games.

Miami and Clemson have met 14 times prior to this game, with both teams having seven wins each. The Hurricanes took the win back in 2023, winning the game 28-20. The two teams have flip-flopped wins in recent years.

Odds provided by BetOnline

Miami vs. Clemson Odds

Miami: -14.5 (-115)

Clemson: +14.5 (-105)

Over: 48.5 (-110)

Under: 48.5 (-110)

Miami vs. Clemson Key Injuries

Miami- TE Owen Ruskavich (Out), RB Mark Fletcher Jr. (Questionable), WR Joshua Moore (Out), RB CharMar Brown (Out), TE Luka Gilbert (Out)

Clemson- RB Jay Haynes (Out), QB Christopher Vizzina (Questionable), RB David Eziomume (Out), CB Corian Gipson (Out), WR Keil McGriff (Out), WR Cole Turner (Out), RB Peyton Streko (Out)

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Miami vs. Clemson Betting Trends

  • Hurricanes are 7-0 ATS in their last 7 games on grass.
  • Hurricanes are 7-0 ATS in their last 7 games after accumulating more than 450 total yards in their previous game.
  • Over is 5-0 in Hurricanes last 5 games on grass.
  • Hurricanes are 4-0 ATS in their last 4 games as a road underdog.
  • Hurricanes are 8-1 ATS vs. a team with a winning record.

Keys to Miami vs. Clemson matchup

Miami has been on fire as one of the best performing football teams this season, especially with how potent the offense has been. Darian Mensah is at the center of that side's success four games in, throwing for 1,211 yards and 14 touchdowns while adding one rushing score to his name. Mark Fletcher Jr. is questionable for the game, but he has excelled in his appearances in the run game by racking up 36 carries for 230 yards and three touchdowns. Javian Mallory follows him with 25 rushes for 226 yards and three touchdowns, while Malachi Toney commands the receiving corps with 34 catches for 564 yards and six touchdowns.

On Miami's defense, they must find holes in Clemson's attack and prevent the quarterback from building momentum throughout the course of the game. The Hurricanes have balance in the tackling department, having no players over 20 tackles while seeing nine players over 10 tackles. Marquise Lightfoot leads the unit with 17 tackles, four sacks and a forced fumble. As for the secondary, Damon Wilson II leads with three pass deflections while Ethan O'Connor broke up two passes and made an interception.

Clemson will emphasize the need to hit the big plays in this one. While Tait Reynolds has been starting in Christopher Vizzina's place at quarterback due to injury, they seem to have recovered some ground after suffering a brutal loss in the season opener. Reynolds has performed well given the circumstances, being active with his dual-threat ability. He has completed 54 out of 84 throws for 521 yards and a touchdown and two interceptions, while rushing 41 times for 83 net yards. Gideon Davidson shines in the run game as their star rusher, racking up 59 carries for 346 yards and three touchdowns.

On defense, it is all about the combination of Corey Myrick, Sammy Brown, Jerome Carter III, and Jeremiah Alexander. They stand out as the four defenders with 20 or more tackles each, seeing Myrick lead the way with 35 tackles and a pass deflection. Will Heldt flourishes with his pass rushing with four sacks and counting, while Ashton Hampton has deflected seven passes so far this season.

Miami vs. Clemson Football Prediction and Pick

This matchup between Miami and Clemson looks to be a pivotal one in football conference action, seeing a lot of stakes for Clemson in particular. The Tigers could be due for an important performance from the receiving corps, which has yet to bloom amidst the activity in the run game. However, Miami can counter that with big plays of significant yardage to give the Clemson defense a long night. Regardless, there will be plenty of offensive highlights in this one. Miami gets the win in this one and covers, while the over also hits.

Final Miami vs. Clemson Prediction and Pick: Miami -14.5 (-115) and under 48.5 (-110)