The Lions will not have two of their starting offensive linemen when they play the Bills on Thursday night.
Right tackle Blake Miller (knee) and left guard Christian Mahogany (hip) have both been ruled out for the Week 2 matchup.
Both players were listed as non-participants for all three days of DetroitâÂÂs injury reports this week.
The Lions list Larry Borom as MillerâÂÂs backup and Miles Frazier as MahoganyâÂÂs backup on their unofficial depth chart.
Additionally, Detroit has listed cornerback D.J. Reed (foot) as questionable. He was limited on the injury report estimate for Tuesday and Wednesday.
Defensive back Christian Izien (groin) and offensive lineman Juice Scruggs (knee) are both off the injury report and are expected to play on Thursday night.