The Colts signed cornerback Kenneth Harris to the 53-player roster from the practice squad, the team announced.
The Colts also placed cornerback Cam Taylor-Britt on injured reserve and signed cornerbacks Shemar Bartholomew and Natrone Brooks to the practice squad.
Harris, 24, was twice elevated from the practice squad to the game-day roster. He has played in two games, seeing action on 21 defensive snaps and seven on special teams.
Harris has recorded three tackles and a pass defensed this season.
Taylor-Britt has a groin injury that will keep him out at least the next four games. He has totaled seven tackles, a tackle for loss, a sack, two passes defensed and six special teams stops.