The Indianapolis Colts made several roster moves Saturday ahead of their Week 10 matchup against the Miami Dolphins, activating defensive end Arden Key from injured reserve, signing linebacker West Weeks to their 53-man roster and placing two veterans on injured reserve.

ESPN NFL insider Adam Schefter reported the transactions Saturday afternoon on X, formerly known as Twitter.

“Colts activated DE Arden Key from injured reserve, signed LB West Weeks to their 53-man roster, and placed TE Mo Alie-Cox and LB Akeem Davis-Gaither on injured reserve.”

The moves come as Indianapolis (2-7) looks to snap its five-game losing streak against Miami (1-7) on Sunday at 1 p.m. ET on CBS.

Key's activation provides the Colts with additional depth along their defensive front as they prepare for another AFC matchup. His return also gives Indianapolis another option in its pass-rushing rotation.

Meanwhile, Weeks joins the active roster, giving the organization additional linebacker depth following Davis-Gaither's placement on injured reserve.

The Colts will now have to adjust their defensive rotation with Davis-Gaither sidelined for at least the next four games.

Colts lose Mo Alie-Cox, Akeem Davis-Gaither ahead of Dolphins matchup

Indianapolis also faces an adjustment at tight end following Alie-Cox's placement on injured reserve.

The veteran has served as a blocking presence and receiving option throughout his tenure with the organization. His absence leaves the Colts needing additional contributions from their remaining tight ends.

Both Alie-Cox and Davis-Gaither will miss at least four games under the NFL's injured reserve rules, making their absences significant as Indianapolis attempts to turn its season around.

The Colts enter Sunday's contest following a 27-23 loss to the Dallas Cowboys in Week 9, extending their losing streak to five games.

With Indianapolis sitting at the bottom of the AFC standings, Sunday's matchup presents another opportunity to regain momentum.

The Colts will host the Dolphins at Lucas Oil Stadium as both teams look to improve their records following disappointing starts to the season.