The Patriots will be missing a couple of defensive starters in Buffalo on Sunday.

Head coach Mike Vrabel told reporters at his Friday press conference that cornerback Christian Gonzalez and defensive tackle Christian Barmore have been ruled out for Week 4. Both players are dealing with shoulder injuries that kept them from practicing this week.

Gonzalez had eight tackles and five passes defensed in the first three weeks of the season. Charles Woods is expected to start in his place against the Bills.

Barmore has four tackles, a sack and three quarterback hits this season. Milton Williams, Cory Durden, and Joshua Farmer will take on more responsibility on the defensive line with Barmore out of action.