he San Francisco 49ers and Buffalo Bills have emerged as the favorites to win Super Bowl LXI following Tuesday's NFL trade deadline, with both organizations strengthening their rosters as they look to maintain their dominance in their respective conferences.
According to BetOnline's latest Super Bowl odds Wednesday, San Francisco leads the field at +575, while Buffalo sits closely behind at +600.
Both teams have opened the season with identical 7-1 records and made significant additions ahead of Tuesday's 4 p.m. ET deadline.
The 49ers acquired veteran wide receiver Keenan Allen from the Indianapolis Colts in exchange for a 2027 sixth-round pick, providing quarterback Brock Purdy with another experienced offensive weapon.
Allen recorded 40 receptions for 351 yards and one touchdown through eight games with Indianapolis this season. His arrival should help San Francisco navigate injuries throughout its receiving corps.
Meanwhile, Buffalo acquired safety Amani Hooker and a 2027 fifth-round pick from the Tennessee Titans in exchange for a 2027 second-round selection.
Hooker enters Buffalo's secondary tied for the NFL lead with five interceptions this season, providing a significant reinforcement to a defense that has struggled against opposing passing attacks.
49ers, Bills look to maintain momentum after trade deadline
San Francisco bounced back from its Week 7 loss to the Atlanta Falcons with a dominant 38-17 victory over the Las Vegas Raiders in Week 9.
Article Continues BelowThe 49ers will look to build on that performance when they visit the Dallas Cowboys (4-5) Sunday at 4:25 p.m. ET on Fox.
Buffalo, meanwhile, enters Week 10 riding a four-game winning streak following its commanding 23-6 victory over the Minnesota Vikings on Monday Night Football.
The Bills will attempt to secure their fifth consecutive victory when they visit the New York Jets (2-6) Sunday at 1 p.m. ET on CBS.
Both organizations will look to justify their status as Super Bowl favorites throughout the second half of the season.