Southampton v Arsenal betting tips and predictions – Can a cupset be on the cards?

Southampton host Arsenal in the FA Cup quarter final at St. Mary’s on Saturday night.

Southampton v Arsenal best bets

• Both teams to score and Arsenal to win – 7/4 with BOYLE Sports
• Arsenal clean sheet – NO – 4/5 with Tote
• Gabriel Jesus and Cyle Larin both to score – 7.4/1 with BOYLE Sports

Southampton v Arsenal latest odds

Find the latest Southampton v Arsenal betting odds here, courtesy of Tote and are subject to change.

• Southampton – 17/2
• Draw – 9/2
• Arsenal – 1/4

Southampton v Arsenal prediction

Arsenal are taking on the third most in form club in the whole of English football’s top four divisions across the last six games on Saturday night.

The Premier League leaders face a potential banana skin FA Cup encounter against a Saints side that have lost just twice in 2026 and unbeaten in 16 matches in all competitions.

This winning momentum tees this game up to be a lot more compelling that it looks on paper.

Cyle Larin has already scored four goals for Southampton since his January arrival, including in their fourth round FA Cup victory over Leicester and could be a big threat to a re-shuffled Arsenal defence.

Midfield man Finn Azaz is the Saints’ top scorer this season with 10 Championship goals. He will have to be stopped at source by the Arsenal midfield engine room.

Arsenal are in a key part of their season coming into the last two months of the season.

The Gunners must respond after humbling 2-0 defeat to Man City in the Carabao Cup final. But will have one eye on their Champions League quarter-final first leg against Sporting on Tuesday night.

Despite being in a great position to pick up silverware this season. His starting line-up will be an important balancing act for Mikel Arteta to strike to maintain momentum with no guarantee of success.

Although, Arsenal are the record holders of the FA Cup, winning the trophy 14 times. Their history in the competition means there’s added prestige there.

Viktor Gyorekes scored four goals across Sweden’s two playoff matches, including 89th minute winner to send his nation to this summer’s World Cup.

The striker will be on cloud nine, but will he start up front on Saturday, with former side Sporting awaiting in Europe?

Southampton v Arsenal betting tips

Both teams to score and Arsenal to win

The Gunners overall quality should prevail over the course of the 90 minutes. But Southampton’s momentum is real and will be bouncing into this game as the longshot underdog.

Saints have really found some form and in every game they’ve played since their 4-0 loss to Middlesbrough way back in January.

It could be enough to get a goal, maybe even two especially in front of their own fans.

The Gunners defence breached

Arsenal’s first choice centre back pairing of William Saliba and Gabriel Magalhaes are some of the most stimy defenders in Europe. Known for shutting down some of the best attacks in world football.

But as Arteta juggles his squad over the coming weeks, they’re back ups may be a little more porous, which could open the door for Southampton to score.

Gabriel Jesus and Cyle Larin both to score

Gabriel Jesus has been on the periphery of the Arsenal team this season. But the cup matches is where he’s got a lot of his minutes since returning from injury.

The Brazilian may get his chance in attack and will be desperate to take it.

Southampton’s Larin will be a danger, especially if he can be fed by playmakers Fin Azaz and if fit, winger Leo Scienza.

The Canadian has four goals for the club, but can he be the cup hero this weekend?

Southampton v Arsenal predicted lineups

Southampton (3-5-2): Peretz; Bree, Harwood-Bellis, Stephens; Manning, Downes, Fellows, Azaz, Charles; Archer, Larin

Arsenal (4-3-3): Kepa; White, Mosquera, Calafiori, Lewis-Skelly; Norgaard, Odegaard, Havertz; Martinelli, Gyorekes, Jesus

How to watch Southampton v Arsenal

• Location: St. Mary’s Stadium, Southampton, UK
• Date and time: Saturday 4th April 2026, 8pm
• How to watch: BBC One, TNT Sports 1, TNT Sports Ultimate, HBO Max

• Both teams to score and Arsenal to win – 7/4 with BOYLE Sports
• Arsenal clean sheet – NO – 4/5 with Tote
• Gabriel Jesus and Cyle Larin both to score – 7.4/1 with BOYLE Sports

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