Opening odds for 49ers-Seahawks in 2026 NFC Divisional round

The 2026 NFC Divisional round will feature an NFC West rivalry showdown featuring the No. 6 San Francisco 49ers visiting the No. 1 Seattle Seahawks this weekend. The two teams split their regular season series with the Niners taking the first matchup way back in Week 1 and the Seahawks closing the campaign with a win in Week 17.

The 49ers were able to march into Philly on Sunday and slip past the reigning Super Bowl champion Eagles in a 23-19 victory, guaranteeing a new team hoisting the Lombardi Trophy this season. They were able to triumph despite suffering another devastating injury with George Kittle tearing his Achilles. Meanwhile, the Seahawks were able to enjoy a first-round bye as a result of the aforementioned Week 17 victory over San Fran.

Below is the current spread, total, and moneyline odds from FanDuel ahead of this divisional round showdown. Seattle opened as a home favorite and is 4-3 against the spread in that scenario this year. Meanwhile, San Francisco is 2-2 against the spread as a road underdog.

Spread: Seahawks -6.5
Total: 45.5
Moneyline: Seahawks -320, 49ers +260