Best betting promos and sportsbooks for NFL prop bets [December 22, 2025]

The Indianapolis Colts look to keep their playoff hopes alive in their matchup against the San Francisco 49ers on Monday night.

With Indianapolis one game back from Houston in the wildcard standings for the last spot in the playoffs, the Colts must finish out their year strong should they want to keep their hopes of playing in the postseason alive. Unfortunately for the Colts, negative regression looms large over their defense as they face off against the San Francisco 49ers who field one of the most explosive offenses in the league.

Even though there is only one game being played on Monday night, there are still plenty of prop bets and markets to groom through which you can read a detailed breakdown of them below.

Best betting promos and sportsbooks for NFL prop bets

Find the best promos and sportsbooks to use for today’s Monday Night Football prop bets.

San Francisco 49ers vs Indianapolis Colts (8:15pm, EST)

Brock Purdy Over 21.5 Pass Completions (-127) at FanDuel Sportsbook

When at full health, Brock Purdy has been one of the most efficient quarterbacks in the league as the San Francisco 49ers signal caller ranks top-5 in Quarterback EPA per Play.

While Purdy has been able to take care of the ball and avoid throwing into high Havoc situations, he has struggled to connect with his pass catchers down the field as he also resides near the bottom of the board in Big Time Throw Percentage.

Luckily for Purdy, he will have a great opportunity to round back into dominant form on Monday night as he faces off against an Indianapolis Colts defensive line who ranks dead last in Pass Rush Win Rate.

With the Colts struggling to get in the backfield, Purdy will be able to avoid having to throw on the run which will help improve the quality of his throws and increase his chances of generating a completion.

Brock Purdy Under 0.5 Interception (+111) at Caesars Sportsbook

Not only have the Colts defensive line struggled to create pressure in the interior, but their back end has steadily fallen down the board in Def DVOA while dealing with injuries.

With their second unit on the field, the 49ers pass catchers will be able to create wider passing lanes for Purdy to throw to while consistently exploiting their gaps in coverage.

Christian McCaffrey Over 61.5 Rushing Yards (-115) at BetMGM Sportsbook

Even though Christian McCaffrey has been able to fill up the stat sheet on a weekly basis, he has been very inefficient with his usage as the 49ers running back ranks well below league average in Yards Over Expected per Attempt. A stunning low level of play from McCaffrey when he gets the benefit of running behind one of the best offensive lines in the league as the 49ers rank top-3 in Run Block Set Grade.

Heading into Monday night, expect McCaffrey to generate explosive runs at a higher rate as he faces off against a Colts front seven who ranks near dead last in Run Defense Line Yards. For some more exposure, escalator bet McCaffrey’s rushing yardage prop by placing smaller wagers on his alternate overs at the best available odds across multiple sportsbooks.

Christian McCaffrey to Record 2+ Touchdowns (+270) at FanDuel Sportsbook

When near the goal line, McCaffrey has been the focal point of the 49ers offense as he currently leads the team in total Red Zone Carries and in Targets.

With the Colts defense falling down the board in Def DVOA as previously mentioned, expect the 49ers to get into scoring position at a higher rate which increases McCaffrey’s chances of scoring multiple touchdowns.

Jonathan Taylor Under 98.5 Rushing Yards (-110) at BetMGM Sportsbook

After getting off to a hot start, Jonathan has fallen hard back down to reality as the Colts running back is averaging less than 4.0 Yards per Carry in his last four games.

A stunning drop off in production as Taylor runs behind an offensive line who ranks top-5 in Run Block PFF Grade.

Unfortunately for Taylor, his struggles in the backfield are poised to persist on Monday night as he faces off against a 49ers defense who ranks above league average in Run Defense Win Rate.

Especially with Phillip Rivers struggling to stretch out the secondary as the 49ers will be able to stack the box which will drastically reduce the quality of Taylor’s running lanes.

About the author

Kody Malstrom

Kody Malstrom is a professional sports bettor and sports betting journalist with six years of experience covering a vast majority of sports. He covers football, basketball, hockey, baseball, and the UFC in written and video form.

Born and raised in Michigan, Kody is a Detroit sports fan who spends all of his Sundays in the fall rooting for the Detroit Lions and Saturdays watching as much College Football as possible. In the winter, he shifts his focus to the Detroit Red Wings and Pistons while simultaneously rooting for his North Carolina Tar Heels.

When he is not staring at betting markets, you can find Kody at the beach or snowboarding down a mountain, depending on the time of the year.

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