C.J. Stroud threw his second touchdown pass of the day, an easy 7-yard flip to David Montgomery. It was the running backâÂÂs third touchdown in his Houston debut.
The sixth lead change of the game has given the Texans a 28-27 lead with 13:34 remaining.
The Texans converted two fourth downs in the 13-play, 72-yard drive. Montgomery had a 2-yard run on fourth-and-1 at the Houston 37 and backup running back Woody Marks ran for 3 yards on fourth-and-1 at the Buffalo 22.
Montgomery now has 18 carries for 59 yards and two touchdowns and three catches for 19 yards and a score.
Stroud is 18-of-26 for 190 yards. He lost a fumble early in the game, which led to a Bills field goal.