NFL picks 2026: Full list of Week 10 predictions with confidence levels

The NFL has made it through the trade deadline and we saw some significant moves this week. The Jaguars went all in on some defensive additions, the 49ers add Keenan Allen to their receiver depth chart, the Bills improved at the safety position, and Kirk Cousins is headed back to Minnesota. Monday and Tuesday were a wild pair of days.

We now head into Week 10 with the Bills and 49ers leading the way in Super Bowl odds, but facing some stiff competition. The Jaguars and Broncos are among the teams that will give Buffalo trouble, while the entire NFC North will be competing for playoff berths.

Speaking of the NFC North, we get a huge matchup at Lambeau Field with the Packers hosting the new-look Vikings. The Sunday slate opens with Patriots-Lions in Munich, and closes on Sunday Night Football with a huge Steelers-Bengals contest for AFC North supremacy.

I’m back for another week of picks and finally had a breakthrough week. In Week 9, I finished 13-2 in my picks, thanks to only picking one upset for the weekend. I was 6-0 on my high confidence picks, 5-1 on medium confidence picks, and 2-1 on low confidence picks.

Just a reminder that I pick games straight up with winners and losers, but I also provide a confidence level. I’ll pick each game’s winner and slot the picks based on confidence levels — high, medium, low, and no. A game with three asterisks (***) after it indicates a game where I’m picking the betting underdog to get the win. Whether you have to assign confidence points or not, this will help you know where I’m standing with the picks. And within each group, I’ve ordered them based on confidence within the confidence level.

Jaguars over Titans
Bills over Jets
Rams over Cardinals

Lions over Patriots
49ers over Cowboys
Chiefs over Falcons
Seahawks over Raiders
Vikings over Packers***

Bengals over Steelers
Ravens over Chargers
Texans over Browns
Giants over Commanders
Panthers over Saints***
Dolphins over Colts***