NFL odds, Week 2: Opening lines include 49ers as biggest favorite

Week 2 odds have arrived and we break down the 16 opening lines for the slate.

San Francisco 49ers v Miami Dolphins
San Francisco 49ers v Miami Dolphins
MIAMI GARDENS, FLORIDA - DECEMBER 22: Brock Purdy #13 of the San Francisco 49ers looks on before the play during the second quarter against the Miami Dolphins at Hard Rock Stadium on December 22, 2024 in Miami Gardens, Florida. (Photo by Megan Briggs/Getty Images)
Getty Images

The NFL is wrapping up Week 1, but the first odds of Week 2 have arrived at FanDuel Sportsbook. Teams still playing will not have their opening odds yet for next week, so we’ll update this as new odds arrive.

Week 2 kicks off with the Bills hosting the Lions. Buffalo won a wild one, scoring a touchdown after the two-minute warning to secure a 36-31 win over the Texans. Detroit had to go to overtime and barely hold off a game Saints squad. After the Lions scored a touchdown in overtime, New Orleans advanced down the field and matched the TD. They went for two and the win but came up short after strong Lions coverage.

The Sunday slate includes some fun ones in Week 2. Bengals-Texans and Jaguars-Broncos will be interesting. Saints-Ravens is suddenly an interesting one in its own right. The 49ers are the biggest favorite nex tweek, laying nearly two touchdowns against the Dolphins.

We have some football still to go this week, but Week 2 should be a fun one.

Lions @ Bills

Spread: Bills -3.5
Moneyline: Lions +164, Bills -196
Total: 53.5

Panthers @ Falcons

Spread: Falcons -1.5
Moneyline: Panthers -102, Falcons -116
Total: 43.5

Vikings @ Bears

Spread: Bears -5.5
Moneyline: Vikings +205, Bears -250
Total: 46.5

Eagles @ Titans

Spread: Eagles -7
Moneyline: Eagles -375, Titans +300
Total: 40.5

Steelers @ Patriots

Spread: Patriots -4.5
Moneyline: Steelers +190, Patriots -230
Total: 43.5

Packers @ Jets

Spread: Packers -5.5
Moneyline: Packers -225, Jets +188
Total: 43.5

Browns @ Buccaneers

Spread: Bucs -7.5
Moneyline: Browns +350, Bucs -450
Total: 40.5

Saints @ Ravens

Spread: Ravens -8.5
Moneyline: Saints +370, Ravens -480
Total: 48.5

Bengals @ Texans

Spread: Texans -2.5
Moneyline: Bengals +118, Texans -142
Total: 47.5

Jaguars @ Broncos

Spread: Broncos -2.5
Moneyline: Jaguars +120, Broncos -142
Total: 44.5

Raiders @ Chargers

Spread: Chargers -7.5
Moneyline: Raiders +320, Chargers -405
Total: 44.5

Commanders @ Cowboys

Spread: TBD
Moneyline: TBD
Total: TBD

Seahawks @ Cardinals

Spread: Seahawks -6.5
Moneyline: Seahawks -290, Cardinals +235
Total: 43.5

Dolphins @ 49ers

Spread: 49ers -13.5
Moneyline: Dolphins +640, 49ers -950
Total: 45.5

Colts @ Chiefs

Spread: TBD
Moneyline: TBD
Total: TBD

Giants @ Rams

Spread: TBD
Moneyline: TBD
Total: TBD

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