Jaguars defensive tackle DaVon Hamilton (torn quad) and safety Eric Murray (elbow) are out for the season.
They were two of four players on the team’s roster listed as non-participants on Monday’s injury report.
The Jaguars did not practice but were required to issue an injury report ahead of Thursday night’s game against the Ravens.
Running back Bhayshul Tuten (ankle/foot) and defensive end Travon Walker (rib) were also listed as non-participants.
Walker had his third sack of the season in Sunday’s win over the Colts but played a season-low 28 snaps.
Offensive lineman Ezra Cleveland (knee/ankle), linebacker Branson Combs (shoulder), safety Antonio Johnson (ankle), cornerback Jarrian Jones (ankle), wide receiver Jakobi Meyers (hamstring/ankle) and running back Chris Rodriguez Jr. (hand) were listed as limited.