The 49ers will see the return of wide receiver Deebo Samuel.
Samuel had a full practice Friday and has no injury designation.
He has missed the past two games with his injury, last playing on Oct. 11 against the Seahawks.
The 49ers will play a second consecutive game without wide receiver Mike Evans (Achilles) as the team ruled him out after another week spent rehabbing.
They list cornerback Deommodore Lenoir (foot), cornerback Renardo Green (back), left tackle Trent Williams (shoulder), cornerback Upton Stout (shoulder), linebacker Dre Greenlaw (knee), cornerback Nate Hobbs (adductor) and defensive tackle C.J. West (knee) as questionable.