Christian McCaffrey finished the week practicing fully, while Mike Evans remains questionable and defensive absences complicate San Francisco's fantasy outlook.
The San Francisco 49ers' Week 4 injury report presents two different decisions for fantasy managers ahead of their matchup with the Denver Broncos. Christian McCaffrey's practice progression offers reassurance, but Mike Evans' rib injury requires a contingency plan.
The defense faces uncertainty. Nick Bosa, James Thompson Jr. and Mykel Williams are out, while Dre Greenlaw, Keion White and Jaden Dugger are questionable. Those absences and potential limitations deserve attention from managers considering San Francisco's defense or individual defensive players.
Here's the final injury report for #DENvsSF. The #49ers will be missing some key players, including Nick Bosa, while the #Broncos will only be without Dondrea Tillman. pic.twitter.com/eHvyjtaekx
— Chad Jensen (@ChadNJensen) October 2, 2026
Mike Evans needs a backup plan
Evans did not practice Wednesday or Thursday because of his rib injury before returning for limited participation Friday. He remains questionable, making him the most important offensive availability decision on this report.
The return to practice is a positive development, but limited participation does not establish that he can handle his usual snaps. Managers should weigh any subsequent workload reporting alongside the final availability announcement rather than assume that being active guarantees unrestricted usage.
Keep a replacement available, preferably one whose game has not started when Evans' status becomes clear. Official inactive lists arrive approximately 90 minutes before kickoff, giving managers a final checkpoint before committing to their lineup.
If Evans is inactive, remove him from starting lineups. If he plays, evaluate the risk against your alternatives: a healthy receiver with a dependable role may be preferable if reports suggest restrictions.
KhaDarel Hodge also appears with a knee injury and missed the two practices shown. His Friday participation is not provided, and his game designation is unspecified. Do not interpret those missing details as confirmation of either availability or an expanded role.
Christian McCaffrey remains a fantasy starter
Article Continues BelowMcCaffrey missed Wednesday's practice for a rest day, not an injury. He then participated fully Thursday and Friday, with no specified game designation on the supplied report.
There is no injury basis here for moving him out of fantasy lineups. Managers should treat the Wednesday absence as scheduled maintenance rather than evidence of a setback. His practice availability supports keeping him in starting plans, although it cannot guarantee a particular workload.
Trent Williams also ended the week positively. The offensive tackle's listing included rest and a neck issue, with his participation improving from absent Wednesday to limited Thursday and full Friday.
His Friday return is encouraging for the offense's blocking outlook. However, the report provides no reason to forecast additional carries, rushing yards or touchdowns for McCaffrey because Williams practiced fully.
Defensive injuries lower confidence
Bosa missed all three practices with knee and calf injuries and is ruled out. Thompson followed the same participation pattern with an ankle injury. Mykel Williams practiced on a limited basis throughout the week but is nevertheless out with a knee injury.
Together, those absences reduce available defensive line personnel. Fantasy defenses earn points through sacks and turnovers, so missing pass rush options is relevant when comparing San Francisco with healthier alternatives. It does not automatically make the unit unusable.
White returned to limited practice Friday after two absences because of a hamstring injury. Greenlaw followed that pattern with a quadriceps issue. Dugger is questionable with a shoulder injury; only one limited session is supplied.
Romello Height practiced on a limited basis throughout the week with a hand injury and has no specified designation. For individual defensive player leagues, bench the confirmed absences and monitor questionable players. Prioritize McCaffrey's reassuring practice finish, Evans' availability and defensive depth when finalizing fantasy decisions.