Kyle Shanahan and his squad make their way to Texas, as the San Francisco 49ers take on the Dallas Cowboys on Sunday at 4:25 p.m. ET. It is time to continue the NFL odds series with a 49ers-Cowboys prediction and pick.

San Francisco enters the game sitting at 7-1. They came out the gates firing by winning their first six games against the Los Angeles Rams, the Miami Dolphins, the Arizona Cardinals, the Denver Broncos, the Seattle Seahawks, and the Washington Commanders. Their perfect start ended after losing 29-20 to the Atlanta Falcons, but they have since bounced back by blowing out the Las Vegas Raiders 38-17.

Meanwhile, Dallas has a 4-5 record. They have been shaky to start the season, losing two of their first three contests. Following that start, they beat the Houston Texans 34-30 before losing back-to-back games to the Tampa Bay Buccaneers and the Green Bay Packers. They rebounded with a 38-21 win over the Philadelphia Eagles but took a step back with a 33-30 loss to the Arizona Cardinals. Dallas is coming off a 27-23 road win over the Indianapolis Colts, presenting this upcoming matchup as an important one.

Odds provided by BetOnline

49ers vs. Cowboys Odds

49ers: -4 (-106)

Cowboys: +4 (-114)

Over: 56 (-105)

Under: 56 (-115)

49ers vs. Cowboys Key Injuries

49ers- OT Trent Williams (Questionable), RB Christian McCaffrey (Injured), WR Demarcus Robinson (Injured), WR Mike Evans (Out), LB Dre Greenlaw (Questionable), CB Siran Neal (Injured), CB Nate Hobbs (Questionable), CB Deommodore Lenoir (Questionable), WR Deebo Samuel Sr. (Injured), CB Renardo Green (Questionable), CB Upton Stout (Questionable), DL CJ West (Questionable)

Cowboys- WR KaVontae Turpin (Injured), CB DaRon Bland (Questionable), S Juanyeh Thomas (Doubtful), S Alijah Clark (Questionable), DL Jonathan Bullard (Questionable), S PJ Locke (Out), TE Jake Ferguson (Out), TE Luke Schoonmaker (Injured), LB DeMarvion Overshown (Injured), CB Joey Porter Jr. (Questionable), WR Jonathan Mingo (Out), WR George Pickens (Injured), RB Tyler Goodson (Out), LB Marist Liufau (Injured), TE Brevyn Spann-Ford (Injured), LB Donovan Ezeiruaku (Out), CB Devin Moore (Questionable)

49ers vs. Cowboys Betting Trends

  • Cowboys are 5-0-1 ATS in their last 6 games as a home underdog.

  • 49ers are 5-0 ATS in their last 5 games following a straight up loss.

  • Over is 4-0 in Cowboys last 4 games as an underdog.
  • Cowboys are 2-0-2 ATS in their last 4 games after accumulating more than 350 total yards in their previous game.
  • Over is 4-0 in 49ers last 4 games following a straight up win of more than 14 points.
  • 49ers are 6-1 ATS in their last 7 games as a road favorite.

Keys to 49ers vs. Cowboys matchup

The 49ers' offense will have plenty of chances to find holes in the Cowboys' defense. Brock Purdy has shined as one of the best performing quarterbacks in the country this season, seeking another playoff run to the Super Bowl. He completed 69.1% of his passes for 1,980 yards and 17 touchdowns and five interceptions while rushing 39 times for 201 yards and two touchdowns. Christian McCaffrey has enjoyed a healthy start to the season, leading all rushers with 102 carries for 457 yards and nine touchdowns while catching 36 passes for 270 yards and a touchdown. George Kittle tops receivers with 483 yards and five touchdowns on 38 catches, while Mike Evans comes next with 27 receptions for 420 yards and three touchdowns.

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San Francisco's defense will seek to be explosive with their playmaking against Dallas' offense, especially when Dak Prescott throws the ball into coverage. Fred Warner leads that side of the ball with 65 tackles, 1.5 sacks, one pass deflection, and one forced fumble. Marcus Jones has shined in the secondary with 77 tackles, five forced fumbles, 4.5 TFL, three pass deflections, and one fumble recovery. Dre Greenlaw has been productive with 57 tackles and three TFL, while Renardo Green racks up 30 tackles, six pass deflections and four interceptions to his name.

The Cowboys have one of the most explosive offenses in the entire league, hoping to make their way back to the playoffs following a shaky start to the season. Dak Prescott has been relatively healthy as he looks to put together another efficient showing as a passer. He has completed 64.9% of his passes for 2,381 yards and 16 touchdowns and five interceptions while rushing 25 times for 102 yards and a touchdown. Javonte Williams has one of the best rushers this season, racking up 154 carries for 629 yards and nine touchdowns while catching 24 passes for 127 yards and a touchdown. CeeDee Lamb is the heart of the receiving game with 70 catches for 904 yards and seven touchdowns, while George Pickens assists him with 39 receptions for 533 yards and two touchdowns.

The Cowboys will be busy trying to hold off San Francisco's offense, especially with how versatile it is. Caleb Downs leads that side of the ball with 55 tackles, three pass deflections, three forced fumbles, two TFL, two sacks, and one interception. Dee Winters comes next with 38 tackles, one pass deflection, one interception, and one TFL. DaRon Bland shines in the secondary with 36 tackles, seven pass deflections, and two TFL. Meanwhile, Quinnen Williams and Donovan Ezeiruaku excels with their pass rushing by combining for 68 tackles, 17.5 TFL, 7.5 sacks, and three forced fumbles.

49ers vs. Cowboys Prediction and Pick

This matchup between the 49ers and the Cowboys stands out as an intriguing matchup. San Francisco has serious momentum as they expect to have their top receivers back in the fold. Dallas will cause trouble with its potent offense, but its leaky defense will be vulnerable to explosive plays from Brock Purdy and Christian McCaffrey. The 49ers get the win in this one, while the under also hits.

Final 49ers vs. Cowboys Prediction and Pick: 49ers -4 (-106) and under 56 (-115)